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Retrospective Study of Genetic Risk Factors for Osteosarcoma

Sharon Savage

11 Collaborator(s)

Funding source

National Cancer Institute (NIH)
NCI is collaborating with investigators from Children’s Oncology Group, which includes institutions from Canada, Spain, the United Kingdom, Italy, Turkey, Brazil, and other countries, on a retrospective study of genetic risk factors for osteosarcoma (OS). This study identified SNPs in GRM4, and 2p25.2 associated with OS risk. A replication genome-wide association study, fine mapping of risk loci, and somatic sequencing of tumor tissue are underway.

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